Evaluation the Sensitivity and Specificity of Fucose and Some Biochemical Parameters as an Indicator of Therapeutic Response to Metformin in Polycystic Ovary Syndrome

The present study aimed to evaluate the sensitivity and specificity of fucose some biochemical parameters, as an indicator therapeutic response Metformin in patients with recently diagnosed Polycystic Ovary Syndrome-PCOS undergoing treatment. This was conducted from 1/9/2022 1/11/2022. In 90 blood samples were collected women aged between (35-18) years old. Of these, 30 taken who had been polycystic ovary syndrome a first group-G1, another same group after taking metformin medication second group-G2, compared healthy no history disease (as control group-C). Samples women's clinics external laboratories (after diagnosis doctor) Samarra city/ Salah Ul-Din. includes determination concentration sex hormones(Follicle stimulating hormone-FSH, luteinizing hormone-LH, testosterone) parameters(Galactose, glucose, total fucose-TF, binding protein-FBP) sera under investigation. There significant increase levels FSH Glucose G1 at probability level (P≤0.05). However, there decrease FBP, no-significant difference LH, testosterone, Galactose group. G2 (P≤0.05) Testosterone, Galactose, glucose TF transaminases enzymes also include Receiver operating characteristic-ROC , C showed that Sensitivity recorded highest for galactose area curve outstanding galactose, galactose. then Testosterone fucose. From above results we can conclude may be used diagnostic biomarker treatment metformin. We current considered ovarian cysts, well uremia patients.